CREBBP and acute lymphoblastic leukemia: Furthermore, Holmfeldt et al. also reported various mutation profiles that are characteristic of near-haploid ALL, including NF1 (44%), histone modifiers (64%), CREBBP (32%), CDKN2A/B (22%), histone gene cluster 6p22 (19%) %), IKZF3 (13%) and PAG1 (10%) [109].