With the indispensable role of MPL as an interacting partner for the mutated CALR proteins to exert their oncogenic potential [22,23] and with the lack of MPL expression in BaF3 cells, we had to overexpress wild-type MPL (MPLWT) in those CALR-mutated (CALRMUT) MPN-model cells as well. Here, CALR is linked to myeloproliferative neoplasm.