These are found to secrete MDK, which promotes cisplatin resistance to Oral squamous cell carcinoma (OSCC), Ovarian and lung cancer cells by up-regulation of ATP binding cassette transporter (ABC) family proteins, multidrug-resistance associated protein-1 (MRP1) and ATP binding cassette subfamily C member two protein (ABCC2) via the long non-coding RNA (lncRNA) ANRIL, in tumor cells [20]. This evidence concerns the gene MDK and lung cancer.