Second, data obtained using the bioinformatic resource, the Cardiovascular Disease Knowledge Portal (https://cvd.hugeamp.org/ (accessed on 24 January 2023)), showed that protective alleles of IS-associated SNPs reduce LDL cholesterol (rs1058074, rs12561767, rs12566098, and rs6702742), non-HDL cholesterol (rs12566098), and total cholesterol (rs1058074) levels and increase HDL3 cholesterol levels, thus pointing to the potentially significant participation of SERBP1 polymorphic variants in the development of atherosclerosis and thrombosis. The gene discussed is SERBP1; the disease is cardiovascular disorder.