To our knowledge, this is the first—albeit preliminary—study showing that the epistatic interaction between the dopamine D3 receptor and dysbindin–1 differently modulates the expression levels of key genes involved in neuroplasticity and neuroinflammation in the hippocampus, striatum, and prefrontal cortex, which are key brain areas implicated in schizophrenia. The gene discussed is DRD3; the disease is schizophrenia.