To better understand the molecular sequelae sustained by the epistatic interaction between D3 and DYS, we investigated the transcriptional effects mediated by DYS, D3, and their genetic interaction on the expression levels of key genes involved in neuroplasticity (i.e., GRIN and BDNF) and neuroinflammation (i.e., IL1β, TNFα, and IL6, [50] in the PFC, striatum, and HIPP, which are key brain areas implicated in schizophrenia [51]. The gene discussed is TNF; the disease is schizophrenia.