Certain signaling pathways were differentially targeted by miR-146a-5p in various cancers, including LIF-Stat3 when reported in the endometrium of patients with implantation failure [23], NOTCH 1/2 in endometrial carcinoma [47], and the EGFR, NF-κB, TGF-β, and SMAD4 pathways in other tumor types. The gene discussed is SMAD4; the disease is endometrial carcinoma.