TARDBP and amyotrophic lateral sclerosis: In general, there are two classifications of ALS according to its etiology—95% of patients develop the disease sporadically, and approximately 5% of cases have a family background, the latter being caused by different gene mutations (the C9orf72 gene, Cu/Zn-superoxide dismutase 1 (SOD1) gene, TDP43, and FUS, among others) [3].