Genome-wide association studies and functional studies showed that UBASH3A and its genetic variants contribute to at least five different autoimmune diseases, including type 1 diabetes (T1D) [1,2,3,4,5,6,7,8,9,10,11,12], suggesting a broad role of UBASH3A in autoimmunity. The gene discussed is UBASH3A; the disease is type 1 diabetes mellitus.