Our linear mixed-effects models revealed that the interaction term of UBASH3A and PTPN22 mRNA levels had a statistically significant impact on IL2 mRNA level in CD8+ T cells from T1D cases (p = 0.0009, Table 1), but not in CD4+ T cells (p = 0.62). The gene discussed is PTPN22; the disease is type 1 diabetes mellitus.