CD8A and type 1 diabetes mellitus: Our results show that in T1D CD8+ T cells, there was a statistical interaction between UBASH3A and PTPN22 transcripts, regulating IL2 expression; more UBASH3A and PTPN22 transcripts led to an increase in IL2 expression, as indicated by the positive coefficient estimate for the parameter “UBASH3A × PTPN22 mRNA expression” (Table 1).