Regarding the single nucleotide polymorphisms (SNP) in exon1, as shown in Table 2, there was no difference in ZNF668 protein expression in bladder tumors in the G/A heterozygous cases at the 5′-UTR variant rs2303222 site compared with the G/G homozygous cases. The gene discussed is ZNF668; the disease is urinary bladder neoplasm.