Mice deficient in adipocyte-specific mitochondrial transcription factor A (Tfam) had decreased activity of proteins in complexes I, III, and IV of the electron transport chain (ETC), resulting in inflammation and adipocyte death in WAT, whitening of BAT, lipodystrophy, insulin resistance, hypertension, and cardiac hypertrophy, reflecting the importance of AT mitochondria in systemic metabolism and the cardiovascular system [77]. The gene discussed is TFAM; the disease is lipodystrophy.