NOS3 and diabetes mellitus: If the deregulation in the expression of these was due to other comorbidities—in this case type 2 diabetes mellitus or hypertension—the expression of the miRNAs and NOS3 would not have given us a significant result in the regression, and this would have indicated that the deregulation observed in its expression was not directly associated with CAD but rather with one of these comorbidities or other confounding variables.