In the case of HTN hearts, bioinformatics also proposed an inhibition of MYCN and MYC (z-score < −2.7) and of anti-oxidative/-inflammatory factors (CD28 and CD3, z-score = −2), while suggesting an enhancement of Rictor and CD437 (z-score > 2) and the anti-oxidative mediator NUPR1 (z-score = 2) (Table 3). Here, CD28 is linked to hypertensive disorder.