A potential molecular link between PGM1 and cardiac symptoms (particularly DCM) was proposed by Arimura et al. [258], who found that in stressed rat myocardium, PGM1 binds to an anchoring protein named Z-band alternatively spliced PDS-motif protein (ZASP, homolog of LDB3 in human) and suggested this to be a compensatory cardioprotective mechanism which would be compromised in PGM1-deficient patients. This evidence concerns the gene LDB3 and familial dilated cardiomyopathy.