Furthermore, Kaempferol showed anti-cancer potential via numerous pathways including the inhibition of angiogenesis as well as the expression of VEGF, regulation of hypoxia-inducible factor 1-alpha (HIF-1α) apoptosis induction, induction of G2/M cell cycle arrest and caspase-3-dependent apoptosis [28,29]. This evidence concerns the gene HIF1A and cancer.