INSR and breast cancer: Table 1 shows the characteristics of BC patients with the division into high and low Ir expression levels according to the median (table obtained from Cebulski et al., 2022 [2]). FNDC5/Ir expression in BC patient tissues was observed in the cytoplasm of tumor cells (Figure 1A), while E-cadherin showed membrane expression (Figure 1B). In turn, the expression of N-cadherin was noted in the cytoplasm (Figure 1C). For the transcription factors SNAIL (Figure 1D,E), SLUG (Figure 1F), and TWIST (Figure 1G,H) in BC tumors, we observed cytoplasmic and nuclear expression.