In particular, anthracyclines such as doxorubicin seem to cause the post-transcriptional translocation of calreticulin from the endoplasmic reticulum, where it is involved in the maintenance of Ca2+ homeostasis, to the plasma membrane of tumor cells; surface-exposed calreticulin then acts as an “eat me” signal for phagocytosis by neighboring APCs, which is required for subsequent antigen cross-presentation to cytotoxic T cells [117]. Here, CALR is linked to neoplasm.