Immunogenic cell death involves the translocation of calreticulin on the cell surface, the secretion of ATP, and the release of the non-histone chromatin protein high-mobility group box 1 (HMGB1) and other immunostimulatory molecules that collectively facilitate the recruitment and activation of APCs into the tumor microenvironment, the engulfment of tumor antigens from dying tumor cells and, finally, the optimal antigen presentation to T cells [85,86,87,88,89,90]. Here, HMGB1 is linked to neoplasm.