Deleting Klf5 in the context of acute pancreatitis by itself or in the context of Kras mutations blocks ADM and mPanIN building, resulting in decreased Krt19 and Ccnd1 and upregulated levels of Ndrg2, which were correlated with the reduced level of STAT3 phosphorylation [111]. The gene discussed is KLF5; the disease is acute pancreatitis.