Recently, adult skin fibroblasts from T1D patients were transformed using mRNAs encoding octamer-binding protein 4 (OCT4), SRY-box transcription factor 2 (SOX2), KLF4, MYC proto-oncogene, BHLH transcription factor (c-MYC), and lin-28 homolog A (LIN28) transcription factors. This evidence concerns the gene POU5F1 and type 1 diabetes mellitus.