KLF6 and Insulin resistance: KLF6 promotes β-cell proliferation and regulates β-cell de- and transdifferentiation into glucagon-producing α-cells, whereas in vivo knockdown of Klf6 has the opposite effect on β-cell proliferation and de/transdifferentiation in the setting of gestational, diet-induced, and insulin receptor antagonist-induced insulin resistance [43] (Figure 1C).