CCND1 and familial pancreatic carcinoma: Additionally, in pancreatic cancer cells, upon KLF10 deletion, activation of the TGFβ and WNT pathway was observed by increased levels of active-β-catenin, c-MYC, survivin, cyclin D1, and Twist family bHLH transcription factor 2 (TWIST2), and stem cell markers such as CD133, CD44, nestin, and ATP-binding cassette subfamily G member 2 (ABCG2) [127].