Moreover, the decrease in farnesoid X receptor signaling during liver inflammation leads to a reduction of hepatic bile acid transporters such as BSEP, OSTα/β, MRP2, MDR2-3, and NTCP, leading to an increase in the concentration of bile acid and persistent inflammation in the liver, which could facilitate the occurrence of HCC [9,29]. The gene discussed is NR1H4; the disease is hepatocellular carcinoma.