Bone marrow (BM) transplantation transferring BM from caspase-1/11-, Nlrp3-, Asc-, Il1b- or Il18-deficient mice to Ldlr−/− animals, showed that inflammasome-mediated inflammatory signaling in the hematopoietic compartment, especially in macrophages, is critical for atherosclerosis development [19,68]. The gene discussed is IL1B; the disease is atherosclerosis.