CASP1 and atherosclerosis: P2X7 expression was increased in human [189] and murine [188] atherosclerotic lesions and deficiency in p2x7 led to reduced caspase-1 and inflammasome activation upon stimulation with LPS and oxLDL, respectively, and reduced atherosclerotic lesions and macrophage recruitment in murine models of atherosclerosis [188,189].