APOE and Atherosclerotic lesion: Endocytosis of oxLDL and subsequent crystallization have been shown to be mediated by the PRR cluster of differentiation 36 (CD36), as Cd36-deficient BMDMs failed to secrete IL-1β upon oxLDL stimulation and Apoe−/− Cd36−/− mice on WD presented with smaller atherosclerotic lesions and reduced IL-1β serum levels compared to Apoe−/− mice [186].