As the role of NLRs as essential players in obesity and its associated morbidities is only beginning to emerge, and associations are so far only known for NOD1, NOD2, NLRP3, NLRP6, NLRP12 and NLRC5, it would be of interest to elucidate a potential role for the other known NLR family members in obesity. The gene discussed is NLRP6; the disease is obesity due to melanocortin 4 receptor deficiency.