Moreover, the NLRP3 rs10754558 polymorphism, which leads to higher production of IL-1β [147] and thus resembles a gain-of-function mutation, and the IL1B rs16944 polymorphism have been associated independently by various groups with T2DM [148,149,150] and obesity [150]. This evidence concerns the gene IL1B and obesity due to melanocortin 4 receptor deficiency.