In line, the increased abundance of Erysipelotrichaceae found in the gut of Nlrp12-deficient animals could be associated with the obesity phenotype, whereas supplementation with Lachnospiraceae, a bacterial species reduced in abundance in the gut of Nlrp12 KO animals, or short chain fatty acids (SCFAs) reduced weight gain and inflammation in Nlrp12-deficient mice and improved glucose metabolism and insulin sensitivity [115]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.