NLRP3 and ataxia telangiectasia: The interference of IL-1β with glucose metabolism is further supported by a study finding IL-1 receptor (IL-1R)-deficient mice to be protected from HFD-induced AT inflammation and impaired glucose sensitivity [145] and by another study proving NLRP3 inflammasome activation in pancreatic islet-infiltrating macrophages to lead to β cell dysfunction [146].