Studies in mice show that deletion of Nlrp3 protects against HFD-induced obesity, IR, dyslipidemia as well as infiltration of macrophages into the AT [59,63,64,140], and leads to improved serum glucose and insulin levels and insulin signaling in liver and cardiac tissue [64,65,140]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.