NLRP6 and metabolic dysfunction-associated steatotic liver disease: However, despite the seemingly beneficial influence of NLRP3 and NLRP6 on the stability of the intestinal barrier and subsequently liver homeostasis, a protective effect of Nlrp3 deficiency in NAFLD and liver inflammation and fibrosis in mice on a choline-deficient amino acid-defined (CDAA) diet was shown, which was attributed, among other things, to the lower production of IL-1β [67] (Figure 2, panel 5).