The OPLS model to distinguish men with AD without T2DM (A+D-) from men without AD with T2DM (A-D+) also showed positive correlations with SHBG and positive and negative correlations with different steroids, and the discriminatory power of the OPLS model, which explained 84.8% (77.4% after cross-validation) of the total variation in the explained variable, was absolute (Table 10). This evidence concerns the gene SHBG and Alzheimer disease.