CRP and obesity due to melanocortin 4 receptor deficiency: In our treatment group, the mean BMI was 35.0 kg/m2 as compared to 28.79 kg/m2 in the study by Rajkumar et al. Since higher BMI is associated with increased CRP levels [35,36], which was also confirmed in our baseline correlations, there is a possibility that the supplementation was not sufficient to address the more severe inflammatory status in our subjects with obesity.