In a very recent study by Kostecka et al., it has been presented that structural chromosomal aberrations and clearly pathogenic point variants in crucial breast cancer driver genes such as PIK3CA, TP53, AKT1, MAP3K1, etc., are frequent in the normal mammary glandular tissue that remains after breast-conserving surgery, demonstrating a complex landscape of mutational burden in the seemingly normal mammary glandular tissue [50]. This evidence concerns the gene PIK3CA and breast cancer.