The neuroprotective effect of andrographolide on a PD cellular model was demonstrated by using MPP+-induced neuronal toxicity in SH-SY5Y cells, in which andrographolide promoted mitophagy mediated by PINK/Parkin signaling pathway and autophagy as indicated by the upregulations of Beclin1, LC3, and LAMP1. Here, PRKN is linked to Parkinson disease.