For instance, Andro could increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) in rats with middle cerebral artery occlusion (MCAO)-induced ischemic stroke, which upregulated p38 MAPK signaling [15]. The gene discussed is NFE2L2; the disease is ischemic stroke.