Supplementation with CTE did not prevent the obesity-induced changes in the mRNA levels of IL-10 and Nox-1 but it prevented the increase in Mcp-1 (p < 0.05), IL-1β (p < 0.05), IL-6 (p < 0.05), Tnf-α (p < 0.05), Nox-1 (p < 0.05) and Ho-1 (p < 0.05) as well as the obesity-induced decrease in the gene expression of Sod-1 (p < 0.001), Gpx-3 (p < 0.05) and Gsr (p < 0.05). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.