Supplementation with CTE did not increase the mRNA levels of Pgc-1α but it attenuated the obesity-induced downregulation of Fasn (p < 0.01), Lpl (p < 0.05), Hsl (p < 0.01), Ppar-γ (p < 0.05), Ucp-1 (p < 0.05), β3-Adr (p < 0.05) and Ob-r (p < 0.05). The gene discussed is IGKV4-1; the disease is obesity due to melanocortin 4 receptor deficiency.