Supplementation with CTE did not prevent the obesity-induced changes in the mRNA levels of IL-10 and Gsr, but it prevented the increase in Mcp-1 (p < 0.01), IL-1β (p < 0.05), IL-6 (p < 0.05), Tnf-α (p < 0.05) and Nox-1 (p < 0.05) as well as the obesity-induced decrease in the gene expression of Nox-4 and Sod-1 (p < 0.05 for both). The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.