NFE2L2 and metabolic syndrome: Moreover, in skeletal muscle, the positive effects of CTE preventing MetS-induced insulin resistance, reducing the gene expression of proinflammatory markers and upregulating the mRNA levels of antioxidant enzymes are associated with an overexpression of Ahr, Arnt and Nrf2. Indeed, as previously reported after resveratrol supplementation [72], the upregulation of AhR and ARNT genes in CTE-treated mice is associated with a positive correlation with NRF2 and with the gene expression of antioxidant enzymes Sod-1, Gpx-3 and Gsr.