Obesity was associated with a significant reduction in the gene expression of Fasn (p < 0.05), Lpl (p < 0.01), Hsl (p < 0.001), Ppar-γ (p < 0.001), Pgc-1α (p < 0.001), Ucp-1 (p < 0.05), β3-Adr (p < 0.001) and Ob-r (p < 0.05). The gene discussed is FASN; the disease is obesity due to melanocortin 4 receptor deficiency.