In WT mice, CLP after LPS tolerance (LPS-CLP) also demonstrated the highest mortality rate as all mice died within 96 h of the observation, while approximately 25% of the mice survived at 96 h post-surgery with CLP alone (Figure 9B), supporting more severe sepsis after LPS tolerance similar to Ezh2 control mice (Figure 7A–L). Here, EZH2 is linked to Sepsis.