Between Ezh2 null versus Ezh2 control mice with CLP-induced sepsis hyperinflammation (CLP) and LPS tolerance with subsequent sepsis (LPS-CLP), sepsis severity was more severe in Ezh2 control mice as indicated by survival analysis, organ injury (kidney and liver), cell-free DNA, endotoxemia, bacteremia, and serum cytokines (TNF-α and IL-6, but not IL-10) (Figure 7C–L), supporting a beneficial impact of Ezh2 deletion in macrophages during sepsis in both conditions. Here, EZH2 is linked to bacterial infectious disease with sepsis.