EZH2 and Sepsis: However, Ezh2 inhibitor attenuated disease severity only in CLP alone, but not LPS-CLP (Figure 9B), perhaps because of the more severe sepsis in LPS-CLP compared with CLP alone, as indicated by higher cell-free DNA and serum cytokines (TNF-α and IL-6) in vehicle-administered LPS-CLP mice compared with the CLP alone group (Figure 9E,H,I).