Among the control group, LPS-CLP demonstrated more severe sepsis than CLP alone as indicated by cell-free DNA, bacteremia, and pro-inflammatory cytokines (TNF-α and IL-6), but not other parameters (serum creatinine, alanine transaminase, renal histology score, spleen apoptosis, endotoxemia, and IL-10) (Figure 7C–L and Figure 8). The gene discussed is TNF; the disease is bacterial infectious disease with sepsis.