The results of this study show that rhein can inhibit the expression of p-Akt/Akt and p-mTOR/mTOR-related proteins in the Akt/mTOR signaling pathway in OC cells and mouse tumor tissues and induce autophagy, suggesting that rhein can induce autophagy by inducing the mechanism by which autophagy plays an anticoagulant role, which is related to the inhibition of the Akt/mTOR signaling pathway by rhein (Figure 7). Here, AKT1 is linked to neoplasm.