Sahranavardfard et al. [32] identified miR-205, -15b, -203 and -9 as linked to melanoma status and its pluripotency: these miRNAs were dysregulated in all groups of cell line melanospheres and affected the expression of genes related to stemness (such as OCT4, NANOG, and SOX2), with the effect of promoting the proliferation and motility of malignant cells. The gene discussed is POU5F1; the disease is melanoma.