Considering that the CD46rs1142469 SNP also alters binding sites for Hoxa7 [43], a transcription factor that is frequently dysregulated in MM patients and plays a role in modulating hematopoiesis and cell differentiation [44], it seems conceivable to suggest that the CD46rs1142469 SNP could influence the risk of developing MM by modulating not only CD46 expression, but also the number of specific subsets of B and T cells and IL20− and Hoxa7-mediated signaling pathways. This evidence concerns the gene HOXA7 and Miyoshi myopathy.