Given the relatively strong association of the genetic variants within the CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci on MM risk, we explored whether these variants could modulate host immune responses, serum steroid hormones, circulating immunological proteins, and blood-derived cell populations using data from the HFGP population. This evidence concerns the gene ATG5 and Miyoshi myopathy.