GCG and cancer: Using this 88 DEP list specific to the cytoplasmic compartment, both KEGG (Figure 5B) and Reactome (Figure 5C) pathway analysis of this DEP list revealed a consistent signaling phenotype associated with oncology (“pathways in cancer”; “transcriptional misregulation in cancer”), stress resistance (“oxidative stress-induced senescence”), glucose metabolism (“glucagon signaling pathway”, “pyruvate metabolism”, “glucose metabolism”, “metabolism of carbohydrates”), and longevity regulation and cell fate (“longevity regulating pathway”, “cellular senescence”).