This means that functionality was linked to energy regulation (“glucagon-like Peptide-1 (GLP1) regulates insulin secretion”, “gluconeogenesis”), cell cycle/fate (“retinoblastoma gene in cancer”), cancer biology (“retinoblastoma gene in cancer”, “breast cancer pathway”) and circadian rhythm (“BMAL1:CLOCK, NPAS2 activates circadian genes”) (Figure 4D). The gene discussed is CLOCK; the disease is breast cancer.