LDLR and Hypercholesterolemia: At t = 0, Ldlr-/-.Leiden mice had developed hypercholesterolemia and hypertriglyceridemia that remained stable during the remainder of the study (cholesterol: 5.6-, 4.4- and 3.9-fold increase, all p < 0.001, FFD control vs. chow at t = 0, t = 7 and t = 12 weeks, respectively) (Figure 2C), (triglycerides: 3.9-, 3.2- and 3.8-fold increase, all p < 0.001, FFD control vs. chow at t = 0, t = 7 and t = 12 weeks, respectively) (Figure 2D).