CALR and neoplasm: This scenario involves a specific T cell attack dependent on the participation of antigen-presenting cells and alarmins, such as calreticulin (CRT) in the cell surface, the exposure and release of heat shock proteins 70 and 90 (HSP70 and HSP90, respectively), and the release of ATP, box 1 of the high mobility group of non-histone chromatin protein (HMGB1) [9], and presence of the tumor-specific antigens to achieve a specific response.