Indeed, cytoplasmic P21 phosphorylated by AKT increases cell survival and contributes to taxol resistance in glioblastoma cells [44], cisplatin resistance in testicular and ovarian cancer [45,46], doxorubicin resistance in triple-negative breast cancer cells SUM159 [47] and failure of paclitaxel treatment in human nasal squamous carcinoma RPMI-2650 [48]. This evidence concerns the gene AKT1 and glioblastoma.