In spite of the proapoptotic (tumor suppressor) potential of upregulated genes AKAP12 (logFC 3.36), TGFB2 and BTG2, the group of overexpressed genes CXCL12 (logFC 2.28), ZFP385A and CDKN1A associate with negative regulation of the intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (Figure 3a). The gene discussed is AKAP12; the disease is neoplasm.