GPCs have been shown as well-known and accepted cell surface coreceptors for growth factors such as Wnt/β-catenin, FGF, IGF, VEGF and TGFB and matrix modifying enzymes in many cancer cells, thus being involved in control of tumor growth, metastasis, angiogenesis and ECM [69,70,71]. Here, IGF1 is linked to neoplasm.