HOOK2 and obesity due to melanocortin 4 receptor deficiency: Another study conducted using a large Hispanic population linked maternal obesity or diabetes using differential DNA methylation in the epigenome of the fetus concerning genes (e.g., SLC2A9, HOOK2, APOE LTF, and DUSP22), which are associated with inflammatory regulatory pathways, signaling pathways, and the related symptoms of obesity and diabetes [30].