Saliva IgA was more frequently detected in active patients with RA as assessed by higher ESR and DAS28 levels, higher tender joint counts, worse heath assessment questionnaire (HAQ) scores, and patient global assessment (PGA) compared to negative IgA results (p = 0.031, p = 0.04, p = 0.039; p = 0.006; p = 0.03, respectively). The gene discussed is CD79A; the disease is rheumatoid arthritis.