We report the identification of several rare variants of known vitiligo-associated genes, including three novel missense variants in PTPN22 (c.1108C>A; p.(His370Asn)), NRROS (c.197C>T; p.(Ala66Val)) and HERC2 (c.10969G>A; p. (Val3657Ile)) in family VF-12. Here, PTPN22 is linked to vitiligo.