AKT2 and ovarian carcinoma: Regarding genetic factors, although certain gene mutations, such as breast cancer gene 1 and 2 (BRCA1/2), tumor protein p53 (TP53), epidermal growth factor receptor (EGFR), and AKT serine/threonine kinase 2 (AKT-2) [7], are involved, other mutated genes may also affect the development and progression of ovarian cancer subtypes [8].