We and others have shown that compared to pMMR or MSS colorectal tumors, POLE-mutant colorectal tumors exhibit increased CD8+ lymphocytic infiltration, tumor-infiltrating immune cells with a Th1 phenotype, the expression of cytotoxic T-cell markers, and effector cytokines similar to the degree observed with immunogenic MSI-high colorectal cancers [14,30]. Here, POLE is linked to colorectal neoplasm.