Many works have demonstrated that lncRNAs play an important role in cancer development, such as PVT1 [21] and CCAT2 [22,23] in colorectal cancer, PCAT-1 [24,25] in prostate cancer, PTCSC3 [26] in thyroid cancer, HULC [27], GAS5 [28] in hepatocellular cancer, ANRIL [29] in various cancer, TERC [30] in oral cavity cancer, etc. These lncRNAs are widely used in cancer diagnosis and monitoring, prognosis, and therapeutic responsiveness prediction. Here, HULC is linked to oral cavity cancer.