TNFAIP3 and systemic lupus erythematosus: TNFAIP3 encodes A20, a negative regulator of NF-κB-induced signalling, whereby the non-synonymous polymorphism rs2230926 in the A20 de-ubiquitinase (DUB) domain precipitates the development of autoimmune diseases including SLE [182,183,187].