SNPs in the IL-10 gene promoter (IL-10-3575, IL-10-1082, and IL-10-592) are responsible for producing the anti-inflammatory cytokine IL-10 and have been associated with the development of GPA and ANCA- EGPA, both of which are varying categories of AAV [43]. The gene discussed is IL10; the disease is granulomatosis with polyangiitis.