Considering the syndromes predisposing to prostate cancer, several overlaps with breast or ovarian cancer syndromes emerge (Table 1, Table 2 and Table S1): BRCA1- and BRCA2-associated hereditary cancer syndrome (gene: BRCA1/2) [26,27,28,29], ATM or AT or Louis-Bar syndrome (gene: ATM) [28,38,39,40], and Lynch syndrome (LS) (lft 5–16%). The gene discussed is BRCA1; the disease is Leigh syndrome.