A large case series also described a rate of approximately 5% of GC cases with both diffuse and intestinal-type histology in LF patients [103]; of these, there was a 29% cumulative risk of gastric cancer up to age 64 years in patients with germline mutations of STK11 [104]; a lifetime GC risk of 21% in individuals with Juvenile Polyposis syndrome [105] and approximately 20% in BRCA1/2 mutation carriers [106]. Here, STK11 is linked to gastric cancer.