Based on the recent research on the nosogenesis of CT26+-bearing mice with ND/DOKD and the results of the KEGG pathway analysis, we further structured the underlying IL-17, toll-like receptor 4 (TLR4), HIF-1α, nuclear factor-kappaB (NF-κB) p65 and TNF signaling as the therapeutic pathways in the DOKD treatment of CT26-bearing mice (Figure 5). Here, TLR4 is linked to Norrie disease.