WB revealed that the expression of HIF-1α, MMP9, N-cadherin, VEGFA, and vimentin proteins was significantly decreased (Figure 9c–g; * p < 0.05, ** p < 0.01 and *** p < 0.001) in the LW6-treated group, suggesting that HIF-1α regulated tumor angiogenesis and metastasis by vimentin, MMP9, and VEGFA in CT26+ colon cancer cells. Here, VIM is linked to colonic neoplasm.