To determine the effect of DOKD on CT26+ colon cancer, we compared its effects with a natural diet (ND) on the growth of a mouse model of CT26+ colon cancer, and demonstrated the anti-tumor effect of DOKD on colon cancer in CT26+ mice and explored its potential anti-tumor mechanisms by determining inflammation, migration, and angiogenesis. The gene discussed is DDX53; the disease is malignant colon neoplasm.