TET2 and lymphoma: In lymphomas, the epigenetic modifiers ten-eleven translocation 2 (TET2), DNA methyltransferase 3A (DNMT3A), and isocitrate dehydrogenase 2 (IDH2) are commonly mutated and correlate with heightened hypermethylation of genes involved in TCR signaling and T cell differentiation [75,77,78,143,144,145].