In a study by Gacerez and Sentman, overexpression of T-bet in B7H6-targeted CD4+ CAR T cells increased proinflammatory and Th1 cytokine secretion and cellular cytotoxicity against B7H6-expressing tumor cells in vitro, and prolonged survival in an in vivo mice model [124]. The gene discussed is NCR3LG1; the disease is neoplasm.