Thus far, studies on the function of TNFAIP1 have mainly focused on pathological conditions such as tumors and Alzheimer’s disease, while there are few studies on the function of TNFAIP1 under physiological conditions, in particular, the role of TNFAIP1 in regulating embryonic development is still unknown. Here, TNFAIP1 is linked to early-onset autosomal dominant Alzheimer disease.