TLR4 and cardiovascular disorder: Apart from the well-known TLR4 ligand-lipopolysaccharide (LPS), DAMPs, such as HMGB1, heat shock factors 60, HSP70, fibrinogen, fibronectin, hyaluronan that are also implicated in cardiovascular diseases, are reported to play a role in the activation of TLR4 [77,82,140,141].