Dysregulation of TLR4 signaling plays a critical role in the initiation and/or progression of cardiovascular diseases, such as ischemia-reperfusion injury, atherosclerosis, myocardial infarction, heart failure, dilated cardiomyopathy, hypertension, sepsis neuropsychiatric, and neurodegenerative disorders [64,66,96,97,98,99,100,101,102,103,104]. Here, TLR4 is linked to heart failure.