Recent studies in patients with SARS-CoV-2 infection also revealed activation of TLR4 in the heart and lungs to cause aberrant TLR4 signaling via the MyD88-dependent pathway that contributes to acute lung injury, myocarditis, cardiac complications, and other severe inflammatory complications, such as the hyper inflammation observed in patients with severe COVID-19 [113]. The gene discussed is TLR4; the disease is COVID-19.