PDK4 and familial dilated cardiomyopathy: In addition to strengthening pathogenicity evidence for known candidate genes in humans, studies in dogs have revealed novel susceptibility genes for sudden cardiac death, DCM, or both, such as STRN (striatin), PDK4 (pyruvate dehydrogenase kinase 4), and QIL1/MICOS13 (mitochondrial contact site and cristae organizing system subunit 13) [17,18,19].