This analysis confirmed that the HIF1A rs11549465T allele was an independent from age, body mass and sex, and a protective factor for NEC (OR = 0.19, 95%CI [0.07–0.54], p = 0.002; padjusted = 0.01), while the rs11549467A allele was a protective factor for RDS (OR = 0.24, 95%CI [0.09–0.68], p = 0.007; padjusted = 0.035; Supplemental Table S5). Here, HIF1A is linked to necrotizing enterocolitis.