For example, the CNAs of oncogenes and tumour suppressor genes, such as PIK3CA, CHD1, MYC, PTEN, CCND1, CDKN1B, TP53, CCNE1, NKX3.1, and RB1, have previously been shown to impact prognosis, tumour progression, and disease stage of PCa and other cancers [2,17,18,19,20,21,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37]. Here, PIK3CA is linked to posterior cortical atrophy.