Although BCL2 deletion and reduced expression may appear counterintuitive for tumour cell survival and carcinogenesis, it should be noted that BCL2-deleted tumour cells may alternatively upregulate one or more members of the BCL2 family of anti-apoptotic genes, such as MCL-1 and BCL2L1, to increase cell survival [45]. The gene discussed is BCL2; the disease is neoplasm.