However, during cerebral ischemia, excitotoxic states rapidly downregulate GABAB receptors through phosphorylation/dephosphorylation processes mediated by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and protein phosphatase 2A (PP2A) [46,48,49]. The gene discussed is CAMK2G; the disease is Cerebral ischemia.