Another polyarginine ST2-104 (ARSRLAELRGVPRGL) peptide (Table 1), obtained by the fusion of nona-arginine (R9) with a short peptide aptamer CBD3 from the collapsin response mediator protein 2 (CRMP2), protected neuroblastoma cells SH-SY5Y from death after exposure to glutamate, limited excess calcium intake, blocked apoptosis and autophagy, reduced infarct volumes, and improved neurological scores in MCAO-treated rats [59]. The gene discussed is DPYSL2; the disease is neuroblastoma.