The differences in age (p = 0.001), hypertension (p < 0.001), cystatin C (p = 0.039), and FHS (p = 0.015) were statistically significant between the two groups, which means that age, hypertension, cystatin C, and FHS can be considered as risk factors for WMH in this study. The gene discussed is CST3; the disease is hypertensive disorder.