The differences in age (p = 0.001), hypertension (p < 0.001), cystatin C (p = 0.039), and FHS (p = 0.015) were statistically significant between the two groups, which means that age, hypertension, cystatin C, and FHS can be considered as risk factors for WMH in this study. This evidence concerns the gene CST3 and Hypertension.