Like GLP-1R, α7-nAChR activation by cynandione A, lemairamin, and cinobufagin also increased IL-10 and POMC gene expression, stimulating IL-10/β-endorphin secretion by microglia in animal models of neuropathic and bone cancer pain, resulting in pain reduction through antiallodynic behavior, as verified by the von Frey filament test [37,38,39]. Here, IL10 is linked to bone neoplasm.